Role of Individual T-Cell Epitopes of Theiler’s Virus in the Pathogenesis of Demyelination Correlates with the Ability To Induce a Th1 Response

Intracerebral inoculation of susceptible strains of mice with Theiler’s murine encephalomyelitis virus (TMEV) results in immune-mediated demyelination. Three major T-cell epitopes have previously been identified within the VP1 (VP1(233–250)), VP2 (VP2(74–86)), and VP3 (VP3(24–37)) capsid proteins in...

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Main Authors: Yauch, Robert L., Palma, JoAnn P., Yahikozawa, Hiroyuki, Koh, Chang-Sung, Kim, Byung S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Viral Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC110426/
https://ncbi.nlm.nih.gov/pubmed/9621084
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