NF-κB-Mediated Inhibition of Apoptosis Is Required for Encephalomyocarditis Virus Virulence: a Mechanism of Resistance in p50 Knockout Mice

Apoptosis is a central host defense mechanism to eliminate virus-infected cells. Activation of NF-κB suppresses apoptosis following some types of stimulation in vitro. To test the physiological importance of this pathway in vivo, we studied murine encephalomyocarditis virus (EMCV) infection in mice...

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Detalhes bibliográficos
Main Authors: Schwarz, Edward M., Badorff, Cornel, Hiura, Timothy S., Wessely, Rainer, Badorff, Annette, Verma, Inder M., Knowlton, Kirk U.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Viral Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC110231/
https://ncbi.nlm.nih.gov/pubmed/9621024
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