Isolation and Propagation of Human Papillomavirus Type 16 in Human Xenografts Implanted in the Severe Combined Immunodeficiency Mouse

We report the isolation and propagation of human papillomavirus type 16, the main agent of cervical cancer, using human foreskin fragments implanted in severe combined immunodeficiency mice. The infection produced viral particles, and with each passage of the virus it caused lesions identical to int...

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Detalhes bibliográficos
Main Authors: Bonnez, William, DaRin, Carrie, Borkhuis, Christine, de Mesy Jensen, Karen, Reichman, Richard C., Rose, Robert C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Viral Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC110112/
https://ncbi.nlm.nih.gov/pubmed/9573300
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