Replacement of Loop II of VP1 of the DA Strain with Loop II of the GDVII Strain of Theiler’s Murine Encephalomyelitis Virus Alters Neurovirulence, Viral Persistence, and Demyelination

Theiler’s murine encephalomyelitis viruses, which are murine picornaviruses, can cause central nervous system inflammatory disease. To study the role of loop II in capsid protein VP1, two mutant viruses of strain DA in which DA loop II amino acids were replaced with strain GDVII amino acids were con...

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izdano v:	J Virol
Principais autores:	Wada, Yoshiaki, McCright, Ingeborg J., Whitby, Frank G., Tsunoda, Ikuo, Fujinami, Robert S.
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 1998
Teme:	Viral Pathogenesis and Immunity
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110000/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9696853/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.9.7557-7562.1998
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