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Inhibition of Phosphodiesterase Type IV Suppresses Human Immunodeficiency Virus Type 1 Replication and Cytokine Production in Primary T Cells: Involvement of NF-κB and NFAT

Rolipram, a phosphosdiesterase type IV-specific inhibitor, prevented p24 antigen release from anti-CD3-activated human immunodeficiency virus (HIV)-infected T cells and CD4(+)-cell depletion associated with viral replication in a dose-responsive manner but minimally inhibited T-cell proliferation. M...

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Bibliografiske detaljer
Main Authors: Navarro, Joaquín, Punzón, Carmen, Jiménez, José Luis, Fernández-Cruz, Eduardo, Pizarro, Angel, Fresno, Manuel, Muñoz-Fernández, M. Angeles
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 1998
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC109998/
https://ncbi.nlm.nih.gov/pubmed/9573235
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