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Identification of Specific Nucleotide Sequences within the Conserved 3′-SL in the Dengue Type 2 Virus Genome Required for Replication

The flavivirus genome is a positive-stranded ∼11-kb RNA including 5′ and 3′ noncoding regions (NCR) of approximately 100 and 400 to 600 nucleotides (nt), respectively. The 3′ NCR contains adjacent, thermodynamically stable, conserved short and long stem-and-loop structures (the 3′-SL), formed by the...

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Autores principales: Zeng, Lingling, Falgout, Barry, Markoff, Lewis
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 1998
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC109990/
https://ncbi.nlm.nih.gov/pubmed/9696848
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