The Epstein-Barr Virus Major Latent Promoter Qp Is Constitutively Active, Hypomethylated, and Methylation Sensitive

Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is indispensable for viral DNA replication and episome maintenance in latency. Four promoters, Cp, Wp, Qp, and Fp, are known to drive EBNA1 expression. Here we show that the TATA-less Qp is constitutively active in a variety of EBV-positive [EBV(+)]...

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Autors principals: Tao, Qian, Robertson, Keith D., Manns, Angela, Hildesheim, Allan, Ambinder, Richard F.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1998
Matèries:
Animal Viruses
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC109928/
https://ncbi.nlm.nih.gov/pubmed/9696800
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