Inhibition of Herpes Simplex Virus Replication by a 2-Amino Thiazole via Interactions with the Helicase Component of the UL5-UL8-UL52 Complex

With the use of a high-throughput biochemical DNA helicase assay as a screen, T157602, a 2-amino thiazole compound, was identified as a specific inhibitor of herpes simplex virus (HSV) DNA replication. T157602 inhibited reversibly the helicase activity of the HSV UL5-UL8-UL52 (UL5/8/52) helicase-pri...

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Bibliografske podrobnosti

izdano v:	J Virol
Principais autores:	Spector, F. C., Liang, L., Giordano, H., Sivaraja, M., Peterson, M. G.
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 1998
Teme:	Animal Viruses
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109917/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9696789/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.9.6979-6987.1998
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