Attenuated Replication of Human Immunodeficiency Virus Type 1 with a Didanosine-Selected Reverse Transcriptase Mutation

Ähnliche Einträge

• Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74-->Val or Ile and Val-75-->Leu or Ile) HIV-1 mutants.
  von: Kleim, J P, et al.
  Veröffentlicht: (1996)
• A Leu to Ile but not Leu to Val change at HIV-1 reverse transcriptase codon 74 in the background of K65R mutation leads to an increased processivity of K65R+L74I enzyme and a replication competent virus
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• Attenuated Replication of Human Immunodeficiency Virus Type 1 with a Didanosine-Selected Reverse Transcriptase Mutation
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