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CD4-Immunoglobulin G2 Protects Hu-PBL-SCID Mice against Challenge by Primary Human Immunodeficiency Virus Type 1 Isolates

CD4-immunoglobulin G2 (IgG2) is a fusion protein comprising human IgG2 in which the Fv portions of both heavy and light chains have been replaced by the V1 and V2 domains of human CD4. Previous studies found that CD4-IgG2 potently neutralizes a broad range of primary human immunodeficiency virus typ...

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Udgivet i:J Virol
Principais autores: Gauduin, Marie-Claire, Allaway, Graham P., Olson, William C., Weir, Raymond, Maddon, Paul J., Koup, Richard A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1998
Fag:
Viral Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109861/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9525686/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.4.3475-3478.1998
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