Determinants for Sensitivity of Human Immunodeficiency Virus Coreceptor CXCR4 to the Bicyclam AMD3100

The bicyclam AMD3100 is a potent and selective inhibitor of the replication of human immunodeficiency virus type 1 and type 2 (HIV-1 and HIV-2). It was recently demonstrated that the compound inhibited HIV entry through CXCR4 but not through CCR5. Selectivity of AMD3100 for CXCR4 was further indicat...

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Autors principals: Labrosse, Béatrice, Brelot, Anne, Heveker, Nikolaus, Sol, Nathalie, Schols, Dominique, De Clercq, Erik, Alizon, Marc
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1998
Matèries:
Animal Viruses
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC109787/
https://ncbi.nlm.nih.gov/pubmed/9658078
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