GABA(A )receptor γ2 subunit knockdown mice have enhanced anxiety-like behavior but unaltered hypnotic response to benzodiazepines

BACKGROUND: Gamma-aminobutyric acid type A receptors (GABA(A)-Rs) are the major inhibitory receptors in the mammalian brain and are modulated by a number of sedative/hypnotic drugs including benzodiazepines and anesthetics. The significance of specific GABA(A)-Rs subunits with respect to behavior an...

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Detalhes bibliográficos
Main Authors: Chandra, Dev, Korpi, Esa R, Miralles, Celia P, De Blas, Angel L, Homanics, Gregg E
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1097738/
https://ncbi.nlm.nih.gov/pubmed/15850489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-6-30
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