A Replication-Competent Retrovirus Arising from a Split-Function Packaging Cell Line Was Generated by Recombination Events between the Vector, One of the Packaging Constructs, and Endogenous Retroviral Sequences

Previously we reported the presence of a replication-competent retrovirus in supernatant from a vector-producing line derived from a widely used split-function amphotropic packaging cell line. Rigorous routine screening of all retroviral stocks produced in our laboratory has not, previously or since...

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Détails bibliographiques

Publié dans:	J Virol
Auteurs principaux:	Chong, Heung, Starkey, William, Vile, Richard G.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1998
Sujets:	Gene Therapy
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109708/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9525583/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.4.2663-2670.1998
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