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Hypersensitivity of Ku-Deficient Cells toward the DNA Topoisomerase II Inhibitor ICRF-193 Suggests a Novel Role for Ku Antigen during the G(2) and M Phases of the Cell Cycle

Ku antigen is a heterodimer, comprised of 86- and 70-kDa subunits, which binds preferentially to free DNA ends. Ku is associated with a catalytic subunit of 450 kDa in the DNA-dependent protein kinase (DNA-PK), which plays a crucial role in DNA double-strand break (DSB) repair and V(D)J recombinatio...

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Main Authors: Muñoz, Purificación, Zdzienicka, Malgorzata Z., Blanchard, Jean-Marie, Piette, Jacques
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology (ASM) 1998
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC109166/
https://ncbi.nlm.nih.gov/pubmed/9742097
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