Loss of IκBα-Mediated Control over Nuclear Import and DNA Binding Enables Oncogenic Activation of c-Rel
The IκBα protein is able both to inhibit nuclear import of Rel/NF-κB proteins and to mediate the export of Rel/NF-κB proteins from the nucleus. We now demonstrate that the c-Rel–IκBα complex is stably retained in the cytoplasm in the presence of leptomycin B, a specific inhibitor of Crm1-mediated nu...
Spremljeno u:
| Izdano u: | Mol Cell Biol |
|---|---|
| Glavni autori: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Taylor & Francis
1998
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109129/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9710628/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.9.5445 |
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