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Tumor-Specific PAX3-FKHR Transcription Factor, but Not PAX3, Activates the Platelet-Derived Growth Factor Alpha Receptor

The t(2;13) chromosomal translocation occurs at a high frequency in alveolar rhabdomyosarcoma, a common pediatric tumor of muscle. This translocation results in the production of a chimeric fusion protein derived from two developmentally regulated transcription factors, PAX3 and FKHR. The two DNA bi...

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Udgivet i:Mol Cell Biol
Principais autores: Epstein, Jonathan A., Song, Baoliang, Lakkis, Maha, Wang, Chiayeng
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1998
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC108996/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9632796/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.7.4118
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