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Activation of c-myc Gene Expression by Tumor-Derived p53 Mutants Requires a Discrete C-Terminal Domain

Mutation of the p53 tumor suppressor gene is the most common genetic alteration in human cancer, and tumors that express mutant p53 may be more aggressive and have a worse prognosis than p53-null cancers. Mutant p53 enhances tumorigenicity in the absence of a transdominant negative mechanism, and th...

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Bibliographische Detailangaben
Hauptverfasser: Frazier, Mark W., He, Xiaoping, Wang, JinLing, Gu, Zhengming, Cleveland, John L., Zambetti, Gerard P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 1998
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC108956/
https://ncbi.nlm.nih.gov/pubmed/9632756
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