A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

Age-related macular degeneration (AMD) is the most frequent cause of irreversible blindness in the elderly in developed countries. Our previous studies implicated activation of complement in the formation of drusen, the hallmark lesion of AMD. Here, we show that factor H (HF1), the major inhibitor o...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Hageman, Gregory S., Anderson, Don H., Johnson, Lincoln V., Hancox, Lisa S., Taiber, Andrew J., Hardisty, Lisa I., Hageman, Jill L., Stockman, Heather A., Borchardt, James D., Gehrs, Karen M., Smith, Richard J. H., Silvestri, Giuliana, Russell, Stephen R., Klaver, Caroline C. W., Barbazetto, Irene, Chang, Stanley, Yannuzzi, Lawrence A., Barile, Gaetano R., Merriam, John C., Smith, R. Theodore, Olsh, Adam K., Bergeron, Julie, Zernant, Jana, Merriam, Joanna E., Gold, Bert, Dean, Michael, Allikmets, Rando
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2005
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1088171/
https://ncbi.nlm.nih.gov/pubmed/15870199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501536102
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge