A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

Age-related macular degeneration (AMD) is the most frequent cause of irreversible blindness in the elderly in developed countries. Our previous studies implicated activation of complement in the formation of drusen, the hallmark lesion of AMD. Here, we show that factor H (HF1), the major inhibitor o...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Hageman, Gregory S., Anderson, Don H., Johnson, Lincoln V., Hancox, Lisa S., Taiber, Andrew J., Hardisty, Lisa I., Hageman, Jill L., Stockman, Heather A., Borchardt, James D., Gehrs, Karen M., Smith, Richard J. H., Silvestri, Giuliana, Russell, Stephen R., Klaver, Caroline C. W., Barbazetto, Irene, Chang, Stanley, Yannuzzi, Lawrence A., Barile, Gaetano R., Merriam, John C., Smith, R. Theodore, Olsh, Adam K., Bergeron, Julie, Zernant, Jana, Merriam, Joanna E., Gold, Bert, Dean, Michael, Allikmets, Rando
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2005
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1088171/
https://ncbi.nlm.nih.gov/pubmed/15870199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501536102
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires