A Small Conserved Surface in SUMO Is the Critical Structural Determinant of Its Transcriptional Inhibitory Properties

Small ubiquitin-like modifier (SUMO) modification of sequence-specific transcription factors has profound regulatory consequences. By providing an intrinsic inhibitory function, SUMO isoforms can suppress transcriptional activation, particularly at promoters harboring multiple response elements. Thr...

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Autors principals: Chupreta, Sergey, Holmstrom, Sam, Subramanian, Lalitha, Iñiguez-Lluhí, Jorge A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
Matèries:
Gene Expression
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087732/
https://ncbi.nlm.nih.gov/pubmed/15870296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.10.4272-4282.2005
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