Phase 1 Safety and Pharmacokinetic Study of Chimeric Murine-Human Monoclonal Antibody cαStx2 Administered Intravenously to Healthy Adult Volunteers

Hemolytic-uremic syndrome (HUS) is a serious complication of infection by Shiga toxin-producing Escherichia coli. Shiga toxin type 2 (Stx2) is responsible for the renal toxicity that can follow intestinal infection and hemorrhagic colitis due to E. coli. A chimeric mouse-human antibody, designated c...

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Detalhes bibliográficos
Main Authors: Dowling, Thomas C., Chavaillaz, Pierre A., Young, David G., Melton-Celsa, Angela, O'Brien, Alison, Thuning-Roberson, Claire, Edelman, Robert, Tacket, Carol O.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087672/
https://ncbi.nlm.nih.gov/pubmed/15855500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.5.1808-1812.2005
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