Imidazole Antibiotics Inhibit the Nitric Oxide Dioxygenase Function of Microbial Flavohemoglobin

Flavohemoglobins metabolize nitric oxide (NO) to nitrate and protect bacteria and fungi from NO-mediated damage, growth inhibition, and killing by NO-releasing immune cells. Antimicrobial imidazoles were tested for their ability to coordinate flavohemoglobin and inhibit its NO dioxygenase (NOD) func...

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Detalhes bibliográficos
Main Authors: Helmick, Ryan A., Fletcher, Arin E., Gardner, Anne M., Gessner, Christopher R., Hvitved, Angela N., Gustin, Michael C., Gardner, Paul R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087630/
https://ncbi.nlm.nih.gov/pubmed/15855504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.5.1837-1843.2005
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