Mechanism of Action of a Novel Series of Naphthyridine-Type Ribosome Inhibitors: Enhancement of tRNA Footprinting at the Decoding Site of 16S rRNA

The novel ribosome inhibitors (NRIs) are a broad-spectrum naphthyridine class that selectively inhibits bacterial protein synthesis (P. J. Dandliker et al., Antimicrob. Agents Chemother. 47:3831-3839, 2003). Footprinting experiments, using a range of NRIs and chemical modification agents on Escheric...

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Main Authors: Shen, Linus L., Black-Schaefer, Candace, Cai, Yingna, Dandliker, Peter J., Beutel, Bruce A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087629/
https://ncbi.nlm.nih.gov/pubmed/15855511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.5.1890-1897.2005
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