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Behavior of Thymidylate Kinase toward Monophosphate Metabolites and Its Role in the Metabolism of 1-(2′-Deoxy-2′-Fluoro-β-l-Arabinofuranosyl)-5-Methyluracil (Clevudine) and 2′,3′-Didehydro-2′,3′-Dideoxythymidine in Cells

l-Nucleoside analogs are a new class of antiviral and anticancer agents, several of which are currently used in the clinic. The phosphorylation of these agents to the triphosphate form is thought to be important for exertion of their pharmacological activities. 1-(2′-Deoxy-2′-fluoro-β-l-arabinofuran...

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Detaylı Bibliyografya
Asıl Yazarlar: Hu, Rong, Li, Ling, Degrève, Bart, Dutschman, Ginger E., Lam, Wing, Cheng, Yung-Chi
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2005
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087619/
https://ncbi.nlm.nih.gov/pubmed/15855530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.5.2044-2049.2005
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