Clinical and Microbiological Responses of Volunteers to Combined Intranasal and Oral Inoculation with a Streptococcus gordonii Carrier Strain Intended for Future Use as a Group A Streptococcus Vaccine

Streptococcus gordonii shows promise as a live mucosal vaccine vector for immunization against respiratory pathogens. In preparation for clinical trials to evaluate S. gordonii engineered to express group A streptococcal M protein antigens, we characterized the responses of 150 healthy volunteers to...

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Detalhes bibliográficos
Main Authors: Kotloff, Karen L., Wasserman, Steven S., Jones, Kevin F., Livio, Sofie, Hruby, Dennis E., Franke, Christine A., Fischetti, Vincent A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087407/
https://ncbi.nlm.nih.gov/pubmed/15784582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.4.2360-2366.2005
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