A Monoclonal Antibody That Conveys In Vitro Killing and Partial Protection in Experimental Syphilis Binds a Phosphorylcholine Surface Epitope of Treponema pallidum

Immunization with purified Treponema pallidum outer membrane vesicles (OMV) has previously resulted in high-titer complement-dependent serum bactericidal activity. In this study, OMV immunization resulted in the isolation of a monoclonal antibody, M131, with complement-dependent killing activity. Pa...

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Detalhes bibliográficos
Main Authors: Blanco, David R., Champion, Cheryl I., Dooley, Alek, Cox, David L., Whitelegge, Julian P., Faull, Kym, Lovett, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087381/
https://ncbi.nlm.nih.gov/pubmed/15845516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.5.3083-3095.2005
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