Endocannabinoid activation at hepatic CB(1) receptors stimulates fatty acid synthesis and contributes to diet-induced obesity

Endogenous cannabinoids acting at CB(1) receptors stimulate appetite, and CB(1) antagonists show promise in the treatment of obesity. CB(1)(–/–) mice are resistant to diet-induced obesity even though their caloric intake is similar to that of wild-type mice, suggesting that endocannabinoids also reg...

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Main Authors: Osei-Hyiaman, Douglas, DePetrillo, Michael, Pacher, Pál, Liu, Jie, Radaeva, Svetlana, Bátkai, Sándor, Harvey-White, Judith, Mackie, Ken, Offertáler, László, Wang, Lei, Kunos, George
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087161/
https://ncbi.nlm.nih.gov/pubmed/15864349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200523057
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