p21-Activated Kinase 1 Regulates Microtubule Dynamics by Phosphorylating Tubulin Cofactor B

p21-activated kinase 1 (Pak1) induces cytoskeleton reorganization in part by regulating microtubule dynamics through an elusive mechanism. Using a yeast two-hybrid screen, we identified tubulin cofactor B (TCoB) (a cofactor in the assembly of the α/β-tubulin heterodimers) as an interacting substrate...

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Main Authors: Vadlamudi, Ratna K., Barnes, Christopher J., Rayala, Suresh, Li, Feng, Balasenthil, Seetharaman, Marcus, Stevan, Goodson, Holly V., Sahin, Aysegul A., Kumar, Rakesh
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2005
Teme:
Signal Transduction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1084301/
https://ncbi.nlm.nih.gov/pubmed/15831477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.9.3726-3736.2005
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