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Identification of genes by hybrid ribozymes that couple cleavage activity with the unwinding activity of an endogenous RNA helicase

Novel ribozymes that couple the cleavage activity of hammerhead ribozymes with the unwinding activity of RNA helicase eIF4AI were constructed. This leads to extremely efficient cleavage of the target mRNA, regardless of the secondary structure of the RNA, and eliminates one of the major problems: ma...

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Detalhes bibliográficos
Main Authors: Kawasaki, Hiroaki, Taira, Kazunari
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1084111/
https://ncbi.nlm.nih.gov/pubmed/11964387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvf098
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