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Genetic manipulation of insulin signaling, action and secretion in mice: Insights into glucose homeostasis and pathogenesis of type 2 diabetes

Non-insulin-dependent diabetes mellitus (NIDDM) is a complex heterogeneous polygenic disease characterized mainly by insulin resistance and pancreatic β-cell dysfunction. In recent years, several genetically engineered mouse models have been developed for the study of the pathophysiological conseque...

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Detalhes bibliográficos
Main Authors: Baudry, Anne, Leroux, Loïc, Jackerott, Malene, Joshi, Rajiv L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1084066/
https://ncbi.nlm.nih.gov/pubmed/11943762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvf078
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