Human MRE11 is inactivated in mismatch repair-deficient cancers

Mutations of the ATM and NBS1 genes are responsible for the inherited Ataxia-Telangiectasia and Nijmegen Breakage Syndrome, both of which are associated with a predisposition to cancer. A related syndrome, the Ataxia-Telangiectasia-like disorder, is due to mutations of the MRE11 gene. However, the r...

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Détails bibliographiques
Auteurs principaux: Giannini, Giuseppe, Ristori, Elisabetta, Cerignoli, Fabio, Rinaldi, Christian, Zani, Massimo, Viel, Alessandra, Ottini, Laura, Crescenzi, Marco, Martinotti, Stefano, Bignami, Margherita, Frati, Luigi, Screpanti, Isabella, Gulino, Alberto
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2002
Sujets:
Scientific Reports
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1084012/
https://ncbi.nlm.nih.gov/pubmed/11850399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvf044
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