Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans

Cyclophilin A is the target of the immunosuppressant cyclosporin A (CsA) and is encoded by a single unique gene conserved from yeast to humans. In the pathogenic fungus Cryptococcus neoformans, two homologous linked genes, CPA1 and CPA2, were found to encode two conserved cyclophilin A proteins. In...

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Bibliographic Details
Main Authors: Wang, Ping, Cardenas, Maria E., Cox, Gary M., Perfect, John R., Heitman, Joseph
Format: Artigo
Language:Inglês
Published: Oxford University Press 2001
Subjects:
Scientific Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1083903/
https://ncbi.nlm.nih.gov/pubmed/11415984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kve109
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