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p19(ARF)-independent induction of p53 and cell cycle arrest by Raf in murine keratinocytes
In tumorigenesis of the skin, activated Ras co-operates with mutations that inactivate the tumour suppressor p53, but the molecular basis for this co-operation remains unresolved. Here we show that activation of the Raf/MAP kinase pathway in primary mouse keratinocytes leads to a p53 and p21(Cip1)-d...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2001
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1083816/ https://ncbi.nlm.nih.gov/pubmed/11258707 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kve020 |
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