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Catalysis of serine oligopeptidases is controlled by a gating filter mechanism
Proteases have a variety of strategies for selecting substrates in order to prevent uncontrolled protein degradation. A recent crystal structure determination of prolyl oligopeptidase has suggested a way for substrate selection involving an unclosed seven-bladed β-propeller domain. We have engineere...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1083722/ https://ncbi.nlm.nih.gov/pubmed/11256612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvd048 |
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