Tumorigenic Poxviruses Up-Regulate Intracellular Superoxide To Inhibit Apoptosis and Promote Cell Proliferation

Tumorigenic leporipoxviruses encode catalytically inactive homologs of cellular Cu-Zn superoxide dismutase (SOD1). The function of the orthologous myxoma virus M131R and Shope fibroma virus S131R gene products is uncertain, but they inhibit SOD1 activity by a process linked to binding its copper cha...

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Bibliographic Details
Main Authors: Teoh, Melissa L. T., Turner, Patricia V., Evans, David H.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Transformation and Oncogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1082777/
https://ncbi.nlm.nih.gov/pubmed/15827194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.9.5799-5811.2005
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