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Hyperphosphorylation of EBNA2 by Epstein-Barr Virus Protein Kinase Suppresses Transactivation of the LMP1 Promoter

The Epstein-Barr virus (EBV) BGLF4 gene encodes a serine/threonine protein kinase (PK) that is expressed in the cytolytic cycle. EBV nuclear antigen 2 (EBNA2) is a key latency gene essential for immortalization of B lymphocytes and transactivation of viral and cellular promoters. Here we report that...

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Main Authors: Yue, Wei, Gershburg, Edward, Pagano, Joseph S.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2005
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1082719/
https://ncbi.nlm.nih.gov/pubmed/15827205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.9.5880-5885.2005
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