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Lethal Factor Active-Site Mutations Affect Catalytic Activity In Vitro

The lethal factor (LF) protein of Bacillus anthracis lethal toxin contains the thermolysin-like active-site and zinc-binding consensus motif HEXXH (K. R. Klimpel, N. Arora, and S. H. Leppla, Mol. Microbiol. 13:1093–1100, 1994). LF is hypothesized to act as a Zn(2+) metalloprotease in the cytoplasm o...

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Autors principals: Hammond, S. E., Hanna, P. C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1998
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC108209/
https://ncbi.nlm.nih.gov/pubmed/9573135
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