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Lactoferrin Inhibits the Endotoxin Interaction with CD14 by Competition with the Lipopolysaccharide-Binding Protein

Human lactoferrin (hLf), a glycoprotein released from neutrophil granules during inflammation, and the lipopolysaccharide (LPS)-binding protein (LBP), an acute-phase serum protein, are known to bind to the lipid A of LPS. The LPS-binding sites are located in the N-terminal regions of both proteins,...

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Udgivet i:Infect Immun
Principais autores: Elass-Rochard, Elisabeth, Legrand, Dominique, Salmon, Valerie, Roseanu, Anca, Trif, Mihaela, Tobias, Peter S., Mazurier, Joel, Spik, Genevieve
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1998
Fag:
Host Response and Inflammation
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC107932/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9453600/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.66.2.486-491.1998
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