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Homology Induction: the use of machine learning to improve sequence similarity searches

BACKGROUND: The inference of homology between proteins is a key problem in molecular biology The current best approaches only identify ~50% of homologies (with a false positive rate set at 1/1000). RESULTS: We present Homology Induction (HI), a new approach to inferring homology. HI uses machine lea...

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Main Authors: Karwath, Andreas, King, Ross D
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2002
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC107726/
https://ncbi.nlm.nih.gov/pubmed/11972320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-3-11
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