Examination of the Role of DNA Polymerase Proofreading in the Mutator Effect of Miscoding tRNAs

We previously described Escherichia coli mutator tRNAs that insert glycine in place of aspartic acid and postulated that the elevated mutation rate results from generating a mutator polymerase. We suggested that the proofreading subunit of polymerase III, ɛ, is a likely target for the aspartic acid-...

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Main Authors: Slupska, Malgorzata M., King, Angela G., Lu, Louise I., Lin, Rose H., Mao, Emily F., Lackey, Chantal A., Chiang, Ju-Huei, Baikalov, Claudia, Miller, Jeffrey H.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1998
Teme:
Genetics and Molecular Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC107632/
https://ncbi.nlm.nih.gov/pubmed/9791123
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