A Novel Mechanism for Resistance to the Antimetabolite N-Phosphonoacetyl-l-Aspartate by Helicobacter pylori

The mechanism of resistance to N-phosphonoacetyl-l-aspartate (PALA), a potent inhibitor of aspartate carbamoyltransferase (which catalyzes the first committed step of de novo pyrimidine biosynthesis), in Helicobacter pylori was investigated. At a 1 mM concentration, PALA had no effects on the growth...

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Pubblicato in:	J Bacteriol
Autori principali:	Burns, Brendan P., Mendz, George L., Hazell, Stuart L.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1998
Soggetti:	Physiology and Metabolism
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC107614/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9791105/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.180.21.5574-5579.1998
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