Stable Secondary Structure near the Nicking Site for Adeno-Associated Virus Type 2 Rep Proteins on Human Chromosome 19

Adeno-associated virus serotype 2 (AAV-2) can preferentially integrate its DNA into a 4-kb region of human chromosome 19, designated AAVS1. The nicking activity of AAV-2's Rep68 or Rep78 proteins is essential for preferential integration. These proteins nick at the viral origin of DNA replicati...

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Main Authors: Jang, Ming Y., Yarborough, OrLando H., Conyers, Gary B., McPhie, Peter, Owens, Roland A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2005
Teme:
Genome Replication and Regulation of Viral Gene Expression
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1075745/
https://ncbi.nlm.nih.gov/pubmed/15731249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.6.3544-3556.2005
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