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Acquisition of Five High-M(r) Penicillin-Binding Protein Variants during Transfer of High-Level β-Lactam Resistance from Streptococcus mitis to Streptococcus pneumoniae

Penicillin-resistant isolates of Streptococcus pneumoniae generally contain mosaic genes encoding the low-affinity penicillin-binding proteins (PBPs) PBP2x, PBP2b, and PBP1a. We now present evidence that PBP2a and PBP1b also appear to be low-affinity variants and are encoded by distinct alleles in β...

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Udgivet i:J Bacteriol
Principais autores: Hakenbeck, Regine, König, Andrea, Kern, Izabella, van der Linden, Mark, Keck, Wolfgang, Billot-Klein, Danielle, Legrand, Raymond, Schoot, Bernard, Gutmann, Laurent
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1998
Fag:
Cell Surfaces
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC107097/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9537382/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.180.7.1831-1840.1998
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