Rhythmic Serotonin N-Acetyltransferase mRNA Degradation Is Essential for the Maintenance of Its Circadian Oscillation

Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase [AANAT]) is the key enzyme in melatonin synthesis regulated by circadian rhythm. To date, our understanding of the oscillatory mechanism of melatonin has been limited to autoregulatory transcriptional and posttranslational regulations...

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Autori principali: Kim, Tae-Don, Kim, Jong-So, Kim, Jong Heon, Myung, Jihwan, Chae, Hee-Don, Woo, Kyung-Chul, Jang, Sung Key, Koh, Duk-Su, Kim, Kyong-Tai
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
Soggetti:
Gene Expression
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1069600/
https://ncbi.nlm.nih.gov/pubmed/15798208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.8.3232-3246.2005
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