Identification of Nuclear Import and Export Signals within Fli-1: Roles of the Nuclear Import Signals in Fli-1-Dependent Activation of Megakaryocyte-Specific Promoters

The Ets factor Friend leukemia integration 1 (Fli-1) is an important regulator of megakaryocytic (Mk) differentiation. Here, we demonstrate two novel nuclear localization signals (NLSs) within Fli-1: one (NLS1) is located at the N terminus, and another (NLS2) is within the Ets domain. Nuclear accumu...

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Detalhes bibliográficos
Main Authors: Hu, Wei, Philips, Alana S., Kwok, Juliana C., Eisbacher, Michael, Chong, Beng H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1069587/
https://ncbi.nlm.nih.gov/pubmed/15798196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.8.3087-3108.2005
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