Activity of Hoechst 33258 against Pneumocystis carinii f. sp. muris, Candida albicans, and Candida dubliniensis

Hoechst 33258 is a compound that binds nucleic acids. We report that Hoechst 33258 exhibits antimicrobial activity against Pneumocystis carinii f. sp. muris in a mouse model for P. carinii pneumonia and against Candida albicans and Candida dubliniensis in vitro. Relative to saline treatment, a 14-da...

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Main Authors: Disney, Matthew D., Stephenson, Ruth, Wright, Terry W., Haidaris, Constantine G., Turner, Douglas H., Gigliotti, Francis
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
Assuntos:
Experimental Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1068638/
https://ncbi.nlm.nih.gov/pubmed/15793106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.4.1326-1330.2005
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