Secretion of Proinflammatory Cytokines and Chemokines during Amphotericin B Exposure Is Mediated by Coactivation of Toll-Like Receptors 1 and 2

Amphotericin B (AmB) is a ligand of toll-like receptor 2 (TLR2). Here, we demonstrate the participation of TLR1 in AmB-induced cell activation that led to the secretion of tumor necrosis factor alpha, interleukin 6 (IL-6), and IL-8. Hence, TLR2-TLR1 coactivation serves as the underlying mechanism fo...

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Bibliografiske detaljer
Main Authors: Razonable, Raymund R., Henault, Martin, Lee, Linda N., Laethem, Carmen, Johnston, Paul A., Watson, Harold L., Paya, Carlos V.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2005
Fag:
Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1068636/
https://ncbi.nlm.nih.gov/pubmed/15793154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.4.1617-1621.2005
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