Pharmacokinetic Profile of Tigecycline in Serum and Skin Blister Fluid of Healthy Subjects after Multiple Intravenous Administrations

The pharmacokinetics of tigecycline, when given as a 100-mg loading dose followed by 50 mg every 12 h, were determined in serum and blister fluid. The peak tigecycline concentration and half-life in serum were greater than those in blister fluid. Tigecycline penetrates into blister fluid well, with...

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Main Authors: Sun, Heather K., Ong, Christine T., Umer, Ambreen, Harper, Dawn, Troy, Steven, Nightingale, Charles H., Nicolau, David P.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1068611/
https://ncbi.nlm.nih.gov/pubmed/15793157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.4.1629-1632.2005
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