Development of Cell-Based Assays for In Vitro Characterization of Hepatitis C Virus NS3/4A Protease Inhibitors

A recombinant vaccinia virus, expressing the NS3-to-NS5 region of the N clone of hepatitis C virus (HCV), was generated and utilized both in a gel-based assay and in an enzyme-linked immunosorbent assay (ELISA) to evaluate the pyrrolidine-5,5-trans-lactams, a series of inhibitors of the HCV NS3/4A p...

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Detalhes bibliográficos
Main Authors: Chung, Victoria, Carroll, Anthony R., Gray, Norman M., Parry, Nigel R., Thommes, Pia A., Viner, K. Claire, D'Souza, Eric A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1068595/
https://ncbi.nlm.nih.gov/pubmed/15793116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.4.1381-1390.2005
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