Pharmacokinetics of Oral Doxycycline during Combination Treatment of Severe Falciparum Malaria

The pharmacokinetics of oral doxycycline administered at 200 mg every 24 h were investigated in 17 patients recovering from severe Plasmodium falciparum malaria. The data suggest that the doses of doxycycline currently recommended (circa 3.5 mg/kg of body weight daily) may not be optimal.

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Detalhes bibliográficos
Main Authors: Newton, Paul N., Chaulet, Jean-François, Brockman, Alan, Chierakul, Wirongrong, Dondorp, Arjen, Ruangveerayuth, Ronatrai, Looareesuwan, Sornchai, Mounier, Cyril, White, Nicholas J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1068593/
https://ncbi.nlm.nih.gov/pubmed/15793155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.4.1622-1625.2005
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