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p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity
Adult stem cells in various tissues are relatively quiescent. The cell cycle inhibitor p21(cip1/waf1) (p21) has been shown to be important for maintaining hematopoietic stem cell quiescence and self-renewal. We examined the role of p21 in the regulation of adult mammalian forebrain neural stem cells...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1065728/ https://ncbi.nlm.nih.gov/pubmed/15769947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1272305 |
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